Choline, an essential nutrient found in many foods, has been gaining increasing attention for its potential health benefits.

But with any supplement comes the inevitable question: are there any side effects associated with taking it? Let’s take a look at the evidence and discuss if choline can be a friend or foe.

Does Choline Cause Anxiety?

There is no scientific evidence that suggests choline causes anxiety in humans. In fact, some studies have suggested that it might be beneficial for reducing anxiety-like behaviors.

For example, one study showed that supplementing with choline was able to reduce the symptoms of social defeat stress in rodents. Another study also demonstrated that choline could improve memory and learning ability in rats exposed to chronic stress.

Does Choline Cause Blood Clots?

There is currently no research suggesting that choline increases the risk of blood clots. In fact, some studies suggest that choline may actually help improve circulation by increasing nitric oxide production, which helps relax your blood vessels and improve blood flow. However, more research is needed to confirm these findings.

Can You Take Too Much Choline?

It is not recommended to take more than 3g of choline per day as this can lead to unpleasant side effects such as nausea and vomiting.

Taking too much of a supplement can also disrupt other nutrients in your body so make sure you stick to the recommended daily dose of 500mg – 1g per day for adults.

Also, be aware that some food sources contain high levels of choline so make sure you read nutrition labels carefully when consuming food sources like eggs and fish oil supplements.

Who Should Not Take It?

Choline should not be taken by pregnant women or people with liver disease as it can increase the risk of liver damage and other complications due to its effect on fat metabolism.

People taking anticoagulants or those with bleeding disorders should also avoid taking choline as it could increase their risk for bleeding complications due to its effect on platelet aggregation.

Lastly, people with allergies should consult their doctor before taking any form of supplement as they may be sensitive to certain ingredients contained within them such as soy lecithin or gelatin capsules used in many forms of choline supplements.


In conclusion, while there are some potential side effects associated with taking a high dose of choline supplements, there is no evidence suggesting that it causes anxiety or blood clots when taken at recommended doses (500mg - 1g/day).

As always though, talk to your doctor before starting a new supplement regimen just to make sure it's safe for you!

With the right precautions and knowledge about what you're putting into your body, choline can definitely be a friend rather than a foe!

And, as always, keep on reading...

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